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Grade 8Science

Cystic Fibrosis

Cystic Fibrosis/ Genetic Disorder Disease Cystic fibrosis (CF) is a genetic disorder that affects the lungs, digestive system, and other organs by causing the body to produce thick, sticky mucus instead of thin, slippery mucus. What causes it? CF is caused by a mutation in the CFTR gene, which controls how salt and water move in and out of cells. When this gene doesn’t work properly, mucus becomes thick and blocks airways and ducts. How does it affect the body? Lungs: Thick mucus traps bacteria → frequent lung infections, coughing, and breathing problems. Digestive system: Mucus blocks enzymes from reaching the intestines → poor digestion and difficulty gaining weight. Sweat glands: Sweat becomes unusually salty. Is it inherited? Yes. CF is an autosomal recessive condition, meaning a child must inherit the faulty gene from both parents to have the disease. Is there a cure? There is no cure, but modern treatments (medications, airway clearance, enzyme supplements) help people with CF live longer and healthier lives.

Practice Quizzes

1.Cystic fibrosis mainly affects which systems?

2.CF is caused by a mutation in which gene?

3.Why do people with CF have breathing problems?

4.CF is inherited when: